Human WDFY1/ WD repeat and FYVE domain-containing protein 1 CLIA Kit

货号:

U8019h

商标:

EIAab^®

监管等级:

RUO

别名:

FYVE domain-containing protein localized to endosomes 1, Phosphoinositide-binding protein 1, WD40- and FYVE domain-containing protein 1, Zinc finger FYVE domain-containing protein 17, FENS-1, FENS1, KIAA1435, WDF1, ZFYVE17

检测方法:

CLIA

特异性:

Natural and recombinant human WD repeat and FYVE domain-containing protein 1

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

规格 & 价格:

关注

Human WDFY1 CLIA Kit

邮箱 *

消息 *

Please 登录.

产品说明书

在线询价

数据
文献
序列 / 3D
反馈墙 (0)

通用注释

亚单元:

Binds PtdIns3P in vitro with high specificity over other phosphoinositides. Interacts (via WD repeat 2) with tyrosine-phosphorylated TLR3 (via TIR domain) in response to poly(I:C) (PubMed:25736436). Interacts with TICAM1 in response to poly(I:C) (By similarity). Interacts with TLR4 in response to LPS (By similarity).

功能:

Positively regulates TLR3- and TLR4-mediated signaling pathways by bridging the interaction between TLR3 or TLR4 and TICAM1. Promotes TLR3/4 ligand-induced activation of transcription factors IRF3 and NF-kappa-B, as well as the production of IFN-beta and inflammatory cytokines (PubMed:25736436).

亚细胞位置:

Early endosome

数据库链接

UniGene:

Hs.368359

STRING:

9606.ENSP00000233055

KEGG:

hsa:57590

Pfam:

PF01363

Uniprot: