VWC2L (基因名), von Willebrand factor C domain-containing protein 2-like (蛋白名), vwc2l_human.
产品名称:
Human VWC2L/ von Willebrand factor C domain-containing protein 2-like CLIA Kit
货号:
-
商标:
EIAab®
监管等级:
别名:
Brorin-like
检测方法:
CLIA
特异性:
Natural and recombinant human von Willebrand factor C domain-containing protein 2-like
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
-
通用注释
亚单元:
Peripherally associated with AMPAR complex. AMPAR complex consists of an inner core made of 4 pore-forming GluA/GRIA proteins (GRIA1, GRIA2, GRIA3 and GRIA4) and 4 major auxiliary subunits arranged in a twofold symmetry. One of the two pairs of distinct binding sites is occupied either by CNIH2, CNIH3 or CACNG2, CACNG3. The other harbors CACNG2, CACNG3, CACNG4, CACNG8 or GSG1L. This inner core of AMPAR complex is complemented by outer core constituents binding directly to the GluA/GRIA proteins at sites distinct from the interaction sites of the inner core constituents. Outer core constituents include at least PRRT1, PRRT2, CKAMP44/SHISA9, FRRS1L and NRN1. The proteins of the inner and outer core serve as a platform for other, more peripherally associated AMPAR constituents, including VWC2L. Alone or in combination, these auxiliary subunits control the gating and pharmacology of the AMPAR complex and profoundly impact their biogenesis and protein processing.
功能:
May play a role in neurogenesis. May play a role in bone differentiation and matrix mineralization.
亚细胞位置:
Secreted
Cell junction
Synapse
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