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Atp6v0a2 (基因名), V-type proton ATPase 116 kDa subunit a isoform 2 (蛋白名), vpp2_mouse.

产品名称:

Mouse Atp6v0a2/ V-type proton ATPase 116 kDa subunit a isoform 2 CLIA Kit
V型质子ATP酶116kDa亚基a亚型2

货号:

U5976m

商标:

EIAab^®

监管等级:

RUO

别名:

Immune suppressor factor J6B7, Lysosomal H(+)-transporting ATPase V0 subunit a2, ShIF, Vacuolar proton translocating ATPase 116 kDa subunit a isoform 2, ISF, V-ATPase 116 kDa isoform a2, Atp6n1b, Tj6

检测方法:

CLIA

实验类型:

Sandwich

检测范围:

39-2500pg/mL

特异性:

Natural and recombinant mouse V-type proton ATPase 116 kDa subunit a isoform 2

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

规格 & 价格:

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产品说明书

说明书:

MSDS:

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通用注释

亚单元:

The V-ATPase is a heteromultimeric enzyme composed of at least thirteen different subunits. It has a membrane peripheral V1 sector for ATP hydrolysis and an integral V0 for proton translocation. The V1 sector comprises subunits A-H, whereas V0 includes subunits a, d, c, c', and c''. Directly interacts with PSCD2 through its N-terminal cytosolic tail in an intra-endosomal acidification-dependent manner (PubMed:16415858). Disruption of this interaction results in the inhibition of endocytosis (PubMed:16415858). Interacts with SPAR/5430416O09Rik.

功能:

Part of the proton channel of V-ATPases (By similarity). Essential component of the endosomal pH-sensing machinery. May play a role in maintaining the Golgi functions, such as glycosylation maturation, by controlling the Golgi pH.

亚细胞位置:

Cell membrane Multi-pass membrane protein Endosome membrane In kidney proximal tubules, detected in subapical early endosomes.

数据库链接

UniGene:

Mm.1158

SMR:

P15920

STRING:

10090.ENSMUSP00000039737

KEGG:

mmu:21871

Pfam: