Rat Vegfa/ Vascular endothelial growth factor A CLIA Kit
血管内皮生长因子A

货号:

U0143r

商标:

EIAab^®

监管等级:

RUO

别名:

Vascular permeability factor, VPF, VEGF-A, Vegf

检测方法:

CLIA

实验类型:

Sandwich

检测范围:

3.9-250pg/mL

特异性:

Natural and recombinant rat Vascular endothelial growth factor A

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

Cancer

规格 & 价格:

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Rat Vegfa CLIA Kit

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产品说明书

说明书:

MSDS:

在线询价

数据
文献 ( 4 )
序列 / 3D
反馈墙 (0)

通用注释

亚单元:

Homodimer; disulfide-linked. Also found as heterodimer with PGF. Interacts with NRP1 (By similarity).

功能:

Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. May play a role in increasing vascular permeability during lactation, when increased transport of molecules from the blood is required for efficient milk protein synthesis. Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity).

亚细胞位置:

Secreted VEGF-A120 is acidic and freely secreted. VEGF-A164 is more basic, has heparin-binding properties and, although a significant proportion remains cell-associated, most is freely secreted. VEGF-A188 is very basic, it is cell-associated after secretion and is bound avidly by heparin and the extracellular matrix, although it may be released as a soluble form by heparin, heparinase or plasmin (By similarity).

数据库链接

UniGene:

Rn.1923

SMR:

P16612

STRING:

10116.ENSRNOP00000026637

KEGG:

rno:83785

Pfam:

PF00341

Uniprot: