VEGFA (基因名), Vascular endothelial growth factor A (蛋白名), vegfa_human.
产品名称:
Human VEGFA/ Vascular endothelial growth factor A CLIA Kit
血管内皮生长因子A
货号:
U0143h
商标:
EIAab®
监管等级:
别名:
Vascular permeability factor, VPF, VEGF-A, VEGF
检测方法:
CLIA
实验类型:
Sandwich
检测范围:
10.9-700pg/mL
特异性:
Natural and recombinant human Vascular endothelial growth factor A
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
Cancer
通用注释
亚单元:
Homodimer; disulfide-linked. Also found as heterodimer with PGF (By similarity). Interacts with NRP1 (PubMed:26503042).
功能:
Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth. Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development.
亚细胞位置:
Secreted
VEGF121 is acidic and freely secreted. VEGF165 is more basic, has heparin-binding properties and, although a signicant proportion remains cell-associated, most is freely secreted. VEGF189 is very basic, it is cell-associated after secretion and is bound avidly by heparin and the extracellular matrix, although it may be released as a soluble form by heparin, heparinase or plasmin.
[1].
K Semeran, P Pawłowski, L Lisowski, et al.
[2].
JS Ouyang, YP Li, CY Li, C Cai, CS Chen, SX Chen, YF Chen, L Yang, YP Xie
From:
Free Radical Research
[3].
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