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Vdac1 (基因名), Voltage-dependent anion-selective channel protein 1 (蛋白名), vdac1_rat.

产品名称:

Rat Vdac1/ Voltage-dependent anion-selective channel protein 1 CLIA Kit
电压依赖性阴离子选择性通道蛋白1

货号:

U12942r

商标:

EIAab^®

监管等级:

RUO

别名:

Outer mitochondrial membrane protein porin 1, VDAC-1

检测方法:

CLIA

特异性:

Natural and recombinant rat Voltage-dependent anion-selective channel protein 1

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

Neurosciences

规格 & 价格:

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通用注释

亚单元:

Interacts with hexokinases including HK1. The HK1-VDAC1 complex interacts with ATF2. Interacts with BCL2L1. Interacts with BAK1. Interacts with BOP/C22orf29 (via BH3 domain). Interacts with beta amyloid and APP; induces VDAC1 dephosphorylation.

功能:

Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective (PubMed:25628567). May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis.

亚细胞位置:

Mitochondrion outer membrane Multi-pass membrane protein Cell membrane Multi-pass membrane protein Membrane raft Multi-pass membrane protein

数据库链接

UniGene:

Rn.54594

STRING:

10116.ENSRNOP00000008477

KEGG:

rno:83529

Pfam:

PF01459

Uniprot: