Vdac1 (基因名), Voltage-dependent anion-selective channel protein 1 (蛋白名), vdac1_mouse.
产品名称:
Mouse Vdac1/ Voltage-dependent anion-selective channel protein 1 CLIA Kit
电压依赖性阴离子选择性通道蛋白1
货号:
U12942m
商标:
EIAab®
监管等级:
别名:
Outer mitochondrial membrane protein porin 1, Plasmalemmal porin, Voltage-dependent anion-selective channel protein 5, VDAC-5, VDAC-1, Vdac5
检测方法:
CLIA
特异性:
Natural and recombinant mouse Voltage-dependent anion-selective channel protein 1
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
Neurosciences
通用注释
亚单元:
Interacts with hexokinases including HK1. The HK1-VDAC1 complex interacts with ATF2. Interacts with BCL2L1. Interacts with BAK1. Interacts with BOP/C22orf29 (via BH3 domain) (By similarity). Interacts with the beta amyloid and APP; induces VDAC1 dephosphorylation (PubMed:25168729).
功能:
Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis.
亚细胞位置:
Isoform Pl-VDAC1
Cell membrane
Multi-pass membrane protein
Membrane raft
Multi-pass membrane protein
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