Mouse Vav3/ Guanine nucleotide exchange factor VAV3 CLIA Kit
VAV-3

货号:

U0219m

商标:

EIAab^®

监管等级:

RUO

别名:

VAV-3

检测方法:

CLIA

特异性:

Natural and recombinant mouse Guanine nucleotide exchange factor VAV3

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

Cancer

规格 & 价格:

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Mouse Vav3 CLIA Kit

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通用注释

亚单元:

Interacts with the PH domain of APS. Interacts with ROS1; constitutive interaction that mediates VAV3 phosphorylation (By similarity). Interacts (via SH2 domains) with the phosphorylated form of EPHA2.

功能:

Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to the nucleotide-free states of those GTPases (By similarity). Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. May be important for integrin-mediated signaling, at least in some cell types. In osteoclasts, along with SYK tyrosine kinase, required for signaling through integrin alpha-v/beta-1 (ITAGV-ITGB1), a crucial event for osteoclast proper cytoskeleton organization and function. This signaling pathway involves RAC1, but not RHO, activation. Necessary for proper wound healing. In the course of wound healing, required for the phagocytotic cup formation preceding macrophage phagocytosis of apoptotic neutrophils. Responsible for integrin beta-2-mediated macrophage adhesion and, to a lesser extent, contributes to beta-3-mediated adhesion. Does not affect integrin beta-1-mediated adhesion.

亚细胞位置:

N/A

数据库链接

UniGene:

Mm.282257

SMR:

Q9R0C8

STRING:

10090.ENSMUSP00000036270

KEGG:

mmu:57257

Pfam: