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VAPA (基因名), Vesicle-associated membrane protein-associated protein A (蛋白名), vapa_human.

产品名称:

Human VAPA/ Vesicle-associated membrane protein-associated protein A CLIA Kit

货号:

商标:

EIAab^®

监管等级:

RUO

别名:

33 kDa VAMP-associated protein, VAP-33, VAMP-A, VAP33

检测方法:

CLIA

特异性:

Natural and recombinant human Vesicle-associated membrane protein-associated protein A

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

Cardiovascular

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通用注释

亚单元:

Homodimer, and heterodimer with VAPB (PubMed:11511104). Interacts with VAMP1, VAMP2, STX1A, BET1, SEC22C and with the C-terminal domain of OCLN (PubMed:11511104, PubMed:9657962, PubMed:10523508). Interacts with OSBPL1A (By similarity). Interacts (via MSP domain) with ZFYVE27; may retain ZFYVE27 in the endoplasmic reticulum and regulate its function in cell projections formation (PubMed:19289470, PubMed:21976701). Interacts with OSBP (PubMed:20178991). Interacts (via C-terminus) with RSAD2/viperin (via C-terminus) (PubMed:21957124). Interacts with HCV protein NS5A and NS5B (PubMed:21957124). Interacts with IFITM3 (PubMed:23601107). Interacts with OSBPL3 (phosphorylated form) (PubMed:16143324, PubMed:25447204). Interacts with KIF5A in a ZFYVE27-dependent manner (PubMed:21976701).

功能:

Binds to OSBPL3, which mediates recruitment of VAPA to plasma membrane sites (PubMed:25447204). The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface (PubMed:25447204). With OSBPL3, may regulate ER morphology (PubMed:16143324). May play a role in vesicle trafficking (PubMed:11511104, PubMed:19289470).

亚细胞位置:

Endoplasmic reticulum membrane Single-pass type IV membrane protein Cell membrane Single-pass type IV membrane protein Cell junction Tight junction Nucleus membrane Present in the plasma membrane and in intracellular vesicles, together with SNARE proteins. May also associate with the cytoskeleton. Colocalizes with OCLN at the tight junction in polarized epithelial cells.

数据库链接

UniGene:

Hs.165195

SMR:

Q9P0L0

KEGG:

hsa:9218

MIM:

605703

Pfam:

PF00635

Uniprot:

Q9P0L0