TARBP2 (基因名), RISC-loading complex subunit TARBP2 (蛋白名), trbp2_bovin.
产品名称:
Bovine TARBP2/ RISC-loading complex subunit TARBP2 CLIA Kit
反式激活应答RNA结合蛋白
货号:
U3425b
商标:
EIAab®
监管等级:
检测方法:
CLIA
特异性:
Natural and recombinant bovine RISC-loading complex subunit TARBP2
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
-
通用注释
亚单元:
Self-associates. Component of the RISC loading complex (RLC), or micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Note that the trimeric RLC/miRLC is also referred to as RISC. Interacts with EIF2AK2/PKR and inhibits its protein kinase activity. Interacts with DHX9 and PRKRA. Interacts with DICER1, AGO2, MOV10, EIF6 and RPL7A (60S ribosome subunit); they form a large RNA-induced silencing complex (RISC).
功能:
Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1.
亚细胞位置:
Cytoplasm
Cytoplasm
Perinuclear region
Nucleus
数据库链接
UniGene:
SMR:
STRING:
KEGG:
Pfam:
Uniprot:
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