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Tnfsf18 (基因名), Tumor necrosis factor ligand superfamily member 18 (蛋白名), tnf18_mouse.

产品名称:

Mouse Tnfsf18/ Tumor necrosis factor ligand superfamily member 18 CLIA Kit
肿瘤坏死因子配合基超家族成员18

货号:

U8960m

商标:

EIAab^®

监管等级:

RUO

别名:

GITR ligand, Glucocorticoid-induced TNF-related ligand, GITRL, Gitrl

检测方法:

CLIA

特异性:

Natural and recombinant mouse Tumor necrosis factor ligand superfamily member 18

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

Immunology

规格 & 价格:

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通用注释

亚单元:

Homotrimer. Homodimer.

功能:

Cytokine that binds to TNFRSF18/AITR/GITR (PubMed:14521928, PubMed:14647196). Regulates T-cell responses (PubMed:14647196). Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation (PubMed:14608036, PubMed:15128759). Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B (PubMed:14521928, PubMed:14647196, PubMed:18178614). Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1 (By similarity). Promotes leukocyte adhesion to endothelial cells (PubMed:23892569). Regulates migration of monocytes from the splenic reservoir to sites of inflammation (PubMed:24107315).

亚细胞位置:

Cell membrane Single-pass type II membrane protein

数据库链接

UniGene:

Mm.276823

SMR:

Q7TS55

STRING:

10090.ENSMUSP00000083251

KEGG:

mmu:240873

Pfam: