TMEM108 (基因名), Transmembrane protein 108 (蛋白名), tm108_bovin.
通用注释
亚单元:
Interacts with DST (isoform 1). Interacts with SH3GL2. Interacts (via N-terminus) with CYFIP1 and CYFIP2; the interactions associate TMEM108 with the WAVE1 complex.
功能:
Transmembrane protein required for proper cognitive functions. Involved in the development of dentate gyrus (DG) neuron circuitry, is neccessary for AMPA receptors surface expression and proper excitatory postsynaptic currents of DG granule neurons. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Through the interaction with DST, mediates the docking of the dynein/dynactin motor complex to vesicle cargos for retrograde axonal transport. In hippocampal neurons, required for BDNF-dependent dendrite outgrowth. Cooperates with SH3GL2 and recruits the WAVE1 complex to facilitate actin-dependent BDNF:NTRK2 early endocytic trafficking and mediate signaling from early endosomes.
亚细胞位置:
Membrane
Multi-pass membrane protein
Cell junction
Synapse
Postsynaptic cell membrane
Postsynaptic density
Endosome membrane
Cell projection
Axon
Cell projection
Dendrite
Early endosome
数据库链接
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