TGFBR2 (基因名), TGF-beta receptor type-2 (蛋白名), tgfr2_chick.
产品名称:
Chicken TGFBR2/ TGF-beta receptor type-2 CLIA Kit
鉴定及受体2型
货号:
U9935c
商标:
EIAab®
监管等级:
别名:
TGF-beta type II receptor, Transforming growth factor-beta receptor type II, TGF-beta receptor type II, TGFR-2
检测方法:
CLIA
实验类型:
Sandwich
特异性:
Natural and recombinant chicken TGF-beta receptor type-2
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
Cancer
通用注释
亚单元:
Heterohexamer; TGFB1, TGFB2 and TGFB3 homodimeric ligands assemble a functional receptor composed of two TGFBR1 and TGFBR2 heterodimers to form a ligand-receptor heterohexamer.
功能:
Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways.
亚细胞位置:
Cell membrane
Single-pass type I membrane protein
Membrane raft
数据库链接
UniGene:
SMR:
STRING:
KEGG:
Pfam:
Uniprot:
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