TFRC (基因名), Transferrin receptor protein 1 (蛋白名), tfr1_pig.
产品名称:
Pig TFRC/ Transferrin receptor protein 1 CLIA Kit
转铁蛋白受体蛋白1
货号:
U0809p
商标:
EIAab®
监管等级:
别名:
CD71, TR
检测方法:
CLIA
实验类型:
Sandwich
检测范围:
0.195-12.5ng/mL
特异性:
Natural and recombinant pig Transferrin receptor protein 1
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
登录.
研究领域:
Neurosciences
通用注释
亚单元:
Homodimer; disulfide-linked. Binds one transferrin or HFE molecule per subunit. Interacts with SH3BP4 (By similarity). Interacts with SH3BP3. Interacts with STEAP3; facilitates TFRC endocytosis in erythroid precursor cells.
功能:
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). Positively regulates T and B cell proliferation through iron uptake.
亚细胞位置:
Cell membrane
Single-pass type II membrane protein
Melanosome
数据库链接
UniGene:
SMR:
STRING:
KEGG:
Pfam:
Uniprot:
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