TEX14 (基因名), Inactive serine/threonine-protein kinase TEX14 (蛋白名), tex14_bovin.
产品名称:
Bovine TEX14/ Inactive serine/threonine-protein kinase TEX14 CLIA Kit
无活性的丝氨酸/苏氨酸蛋白激酶TEX14
货号:
U5438b
商标:
EIAab®
监管等级:
别名:
Testis-expressed sequence 14, Testis-expressed sequence 14 protein
检测方法:
CLIA
特异性:
Natural and recombinant bovine Inactive serine/threonine-protein kinase TEX14
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
-
通用注释
亚单元:
Interacts with KIF23 and RBM44. Interacts with CEP55; inhibiting interaction between CEP55 and PDCD6IP/ALIX and TSG101.
功能:
Required both for the formation of intercellular bridges during meiosis and for kinetochore-microtubule attachment during mitosis. Intercellular bridges are evolutionarily conserved structures that connect differentiating germ cells and are required for spermatogenesis and male fertility. Acts by promoting the conversion of midbodies into intercellular bridges via its interaction with CEP55: interaction with CEP55 inhibits the interaction between CEP55 and PDCD6IP/ALIX and TSG101, blocking cell abscission and leading to transform midbodies into intercellular bridges. Also plays a role during mitosis: recruited to kinetochores by PLK1 during early mitosis and regulates the maturation of the outer kinetochores and microtubule attachment. Has no protein kinase activity in vitro.
亚细胞位置:
Cytoplasm
Midbody
Chromosome
Centromere
Kinetochore
Detected in the intercellular bridges that connect male germ cell daughter cells after cell division.
数据库链接
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