Tacc3 (基因名), Transforming acidic coiled-coil-containing protein 3 (蛋白名), tacc3_mouse.
产品名称:
Mouse Tacc3/ Transforming acidic coiled-coil-containing protein 3 CLIA Kit
货号:
U16086m
商标:
EIAab®
监管等级:
别名:
ARNT-interacting protein, Aint
检测方法:
CLIA
特异性:
Natural and recombinant mouse Transforming acidic coiled-coil-containing protein 3
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
Cancer
通用注释
亚单元:
Interacts with GCN5L2 and PCAF (By similarity). The coiled coil C-terminal region interacts with AH receptor nuclear translocator protein (ARNT) and ARNT2 (PubMed:11025203). Interacts with CCDC100/CEP120 (PubMed:17920017). Interacts with CKAP5 independently of clathrin. Interacts with CKAP5 and clathrin forming the TACC3/ch-TOG/clathrin complex located at spindle inter-microtubules bridges; TACC3 (phosphorylated at Ser-347 by AURKA) and CLTC are proposed to form a composite microtubule interaction surface.
功能:
Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (PubMed:17920017). Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (By similarity). May be involved in the control of cell growth and differentiation. May have a role in embryonic development.
亚细胞位置:
Cytoplasm
Cytoplasm
Cytoskeleton
Microtubule organizing center
Centrosome
Cytoplasm
Cytoskeleton
Spindle pole
In complex with CKAP5 localized to microtuble plus-ends in mitosis and interphase. In complex with CKAP5 and clathrin localized to inter-microtubule bridges in mitotic spindles.
验证序列:
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