Tab2 (基因名), TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 (蛋白名), tab2_mouse.
产品名称:
Mouse Tab2/ TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 CLIA Kit
磷酸化转化生长因子β活化激酶结合蛋白2
货号:
U2882m
商标:
EIAab®
监管等级:
别名:
Mitogen-activated protein kinase kinase kinase 7-interacting protein 2, TAK1-binding protein 2, TGF-beta-activated kinase 1-binding protein 2, TAB-2, Kiaa0733, Map3k7ip2
检测方法:
CLIA
特异性:
Natural and recombinant mouse TGF-beta-activated kinase 1 and MAP3K7-binding protein 2
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
Cancer
通用注释
亚单元:
Interacts with MAP3K7 and TRAF6. Identified in the TRIKA2 complex composed of MAP3K7, TAB1 and TAB2. Binds 'Lys-63'-linked polyubiquitin chains. Interacts with NCOR1 and HDAC3 to form a ternary complex. Interacts (via C-terminal) with NUMBL (via PTB domain). Interacts (via the C-terminus) with WDR34 (via WD domains). Interacts with RBCK1 (By similarity). Interacts with TRIM5.
功能:
Adapter linking MAP3K7/TAK1 and TRAF6. Promotes MAP3K7 activation in the IL1 signaling pathway. The binding of 'Lys-63'-linked polyubiquitin chains to TAB2 promotes autophosphorylation of MAP3K7 at 'Thr-187' (By similarity). Regulates the IL1-mediated translocation of NCOR1 out of the nucleus. Involved in heart development.
亚细胞位置:
Nucleus
Cytoplasm
Cytosol
Cytoplasmic when activated. Following IL1 stimulation, localized in the to cytosol.
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