TM4SF20 (基因名), Transmembrane 4 L6 family member 20 (蛋白名), t4s20_bovin.
产品名称:
Bovine TM4SF20/ Transmembrane 4 L6 family member 20 CLIA Kit
跨膜4l6家族成员20
货号:
U1147b
商标:
EIAab®
监管等级:
检测方法:
CLIA
特异性:
Natural and recombinant bovine Transmembrane 4 L6 family member 20
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
-
通用注释
亚单元:
N/A
功能:
Polytopic transmembrane protein. Inhibits regulated intramembrane proteolysis (RIP) of CREB3L1, inhibiting its activation and the induction of collagen synthesis. In response to ceramide, which alters TM4SF20 membrane topology, stimulates RIP activation of CREB3L1. Ceramide reverses the direction through which transmembrane helices are translocated into the endoplasmic reticulum membrane during translation of TM4SF20, this mechanism is called 'regulated alternative translocation' (RAT) and regulates the function of the transmembrane protein.
亚细胞位置:
Membrane
Multi-pass membrane protein
Endoplasmic reticulum membrane
Multi-pass membrane protein
Ceramide alters the direction through which transmembrane helices are translocated into the endoplasmic reticulum membrane during translation of TM4SF20.
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