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Setd2 (基因名), Histone-lysine N-methyltransferase SETD2 (蛋白名), setd2_mouse.

产品名称:

Mouse Setd2/ Histone-lysine N-methyltransferase SETD2 CLIA Kit

货号:

U14466m

商标:

EIAab^®

监管等级:

RUO

别名:

Lysine N-methyltransferase 3A, Protein-lysine N-methyltransferase SETD2, SET domain-containing protein 2, Kiaa1732, Kmt3a

检测方法:

CLIA

特异性:

Natural and recombinant mouse Histone-lysine N-methyltransferase SETD2

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

规格 & 价格:

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亚单元:

Specifically interacts with hyperphosphorylated C-terminal domain (CTD) of RNA polymerase II large subunit (POLR2A): binds to CTD heptad repeats doubly phosphorylated on 'Ser-2' and 'Ser-5' of each heptad. Interacts with HTT. Interacts with IWS1. Interacts with p53/TP53; leading to regulate p53/TP53 target genes. Component of a complex with HNRNPL. Interacts with TUBA1A; the interaction is independent on alpha-tubulin acetylation on 'Lys-40'.

功能:

Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate (PubMed:18157086, PubMed:20133625). Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation (PubMed:18157086, PubMed:20133625). Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A (By similarity). Acts as a key regulator of DNA mismatch repair in G1 and early S phase by generating H3K36me3, a mark required to recruit MSH6 subunit of the MutS alpha complex: early recruitment of the MutS alpha complex to chromatin to be replicated allows a quick identification of mismatch DNA to initiate the mismatch repair reaction (By similarity). Required for DNA double-strand break repair in response to DNA damage: acts by mediating formation of H3K36me3, promoting recruitment of RAD51 and DNA repair via homologous recombination (HR) (By similarity). Acts as a tumor suppressor (By similarity). H3K36me3 also plays an essential role in the maintenance of a heterochromatic state, by recruiting DNA methyltransferase DNMT3A (By similarity). H3K36me3 is also enhanced in intron-containing genes, suggesting that SETD2 recruitment is enhanced by splicing and that splicing is coupled to recruitment of elongating RNA polymerase (By similarity). Required during angiogenesis (PubMed:20133625). Required for endoderm development by promoting embryonic stem cell differentiation toward endoderm: acts by mediating formation of H3K36me3 in distal promoter regions of FGFR3, leading to regulate transcription initiation of FGFR3 (PubMed:25242323). In addition to histones, also mediates methylation of other proteins, such as tubulins and STAT1 (PubMed:27518565). Trimethylates 'Lys-40' of alpha-tubulins such as TUBA1B (alpha-TubK40me3); alpha-TubK40me3 is required for normal mitosis and cytokinesis and may be a specific tag in cytoskeletal remodeling (PubMed:27518565). Involved in interferon-alpha-induced antiviral defense by mediating both monomethylation of STAT1 at 'Lys-525' and catalyzing H3K36me3 on promoters of some interferon-stimulated genes (ISGs) to activate gene transcription (By similarity).

亚细胞位置:

Nucleus Chromosome

数据库链接

UniGene:

Mm.288949

SMR:

E9Q5F9

STRING:

10090.ENSMUSP00000116313

KEGG:

mmu:235626

Pfam:

PF00856

Uniprot:

E9Q5F9

相关产品

Human SETD2 ELISA Kit

Human SETD2 CLIA Kit

Human SETD2 Protein

Human SETD2 Polyclonal Antibody

Human SETD2 Monoclonal Antibody

序列长度:

2537

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KHKTKEYIKK | Y MQKFGAVY | KPKEDTELE

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