ARHGAP35 (基因名), Rho GTPase-activating protein 35 (蛋白名), rhg35_canlf.
产品名称:
Dog ARHGAP35/ Rho GTPase-activating protein 35 CLIA Kit
货号:
U15803d
商标:
EIAab®
监管等级:
别名:
Glucocorticoid receptor DNA-binding factor 1, Rho GAP p190A, p190-A, GRLF1, P190A, p190ARHOGAP
检测方法:
CLIA
特异性:
Natural and recombinant dog Rho GTPase-activating protein 35
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
-
通用注释
亚单元:
Interacts with RASA1/p120GAP. Interacts with the general transcription factor GTF2I, the interaction sequesters GTF2I in the cytoplasm.
功能:
Rho GTPase-activating protein (GAP), binds several acidic phospholipids which inhibits the Rho GAP activity to promote the Rac GAP activity (By similarity). This binding is inhibited by phosphorylation by PRKCA (By similarity). Involved in cell differentiation as well as cell adhesion and migration, plays an important role in retinal tissue morphogenesis, neural tube fusion, midline fusion of the cerebral hemispheres and mammary gland branching morphogenesis. Transduces signals from p21-ras to the nucleus, acting via the ras GTPase-activating protein (GAP). Transduces SRC-dependent signal from cell-surface adhesion molecules, such as laminin, to promote neurite outgrowth. Regulates axon outgrowth, guidance and fasciculation. Modulates Rho GTPase-dependent F-actin polymerization, organization and assembly, is involved in polarized cell migration and in the positive regulation of ciliogenesis and cilia elongation. During mammary gland development, is required in both the epithelial and stromal compartments for ductal outgrowth.
亚细胞位置:
Cytoplasm
Cytoskeleton
Cilium basal body
Cytoplasm
Cell membrane
In response to integrins and SDC4 and upon phosphorylation by PKC, relocalizes from the cytoplasm to regions of plasma membrane ruffling where it colocalizes with polymerized actin.
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