RAB43 (基因名), Ras-related protein Rab-43 (蛋白名), rab43_human.
产品名称:
Human RAB43/ Ras-related protein Rab-43 CLIA Kit
货号:
U6517h
商标:
EIAab®
监管等级:
别名:
Ras-related protein Rab-41, RAB41
检测方法:
CLIA
特异性:
Natural and recombinant human Ras-related protein Rab-43
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
登录.
研究领域:
-
通用注释
亚单元:
N/A
功能:
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The low intrinsic GTPase activity of RAB43 is activated by USP6NL. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for the structural integrity of the Golgi complex. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis.
亚细胞位置:
Cytoplasmic vesicle
Phagosome
Cytoplasmic vesicle
Phagosome membrane
Lipid-anchor
Cytoplasmic side
Golgi apparatus
Golgi apparatus
Trans-Golgi network membrane
Lipid-anchor
Golgi apparatus
Trans-Golgi network
Recruited to phagosomes containing S.aureus or M.tuberculosis (PubMed:21255211).
数据库链接
UniGene:
SMR:
STRING:
KEGG:
Pfam:
Uniprot:
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