Rab3ip (基因名), Rab-3A-interacting protein (蛋白名), rab3i_mouse.
产品名称:
Mouse Rab3ip/ Rab-3A-interacting protein CLIA Kit
货号:
-
商标:
EIAab®
监管等级:
别名:
Rabin-3, SSX2-interacting protein, Rab3A-interacting protein, Rabin8
检测方法:
CLIA
特异性:
Natural and recombinant mouse Rab-3A-interacting protein
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
-
通用注释
亚单元:
Interacts with the N-terminal region of SSX2. Interacts with the GDP-bound forms of RAB3A, RAB3D, RAB8A and RAB8B.
功能:
Guanine nucleotide exchange factor (GEF) which may activate RAB8A and RAB8B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Mediates the release of GDP from RAB8A and RAB8B but not from RAB3A or RAB5. Modulates actin organization and promotes polarized transport of RAB8A-specific vesicles to the cell surface. Together with RAB11A, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis.
亚细胞位置:
Cytoplasm
Nucleus
Cytoplasm
Cytoskeleton
Cell projection
Lamellipodium
Predominantly cytoplasmic but a small proportion colocalizes with SSX2 in the nucleus. Activation of protein kinase C results in redistribution to the periphery of lamellipodia. In the cytoskeleton, localizes to cortical actin (By similarity).
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