Human RAB35/ Ras-related protein Rab-35 CLIA Kit

货号:

商标:

EIAab^®

监管等级:

RUO

别名:

GTP-binding protein RAY, Ras-related protein Rab-1C, RAB1C, RAY

检测方法:

CLIA

特异性:

Natural and recombinant human Ras-related protein Rab-35

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

Cancer

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Human RAB35 CLIA Kit

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通用注释

亚单元:

Interacts with DENND1A and DENND1B; in a nucleotide-dependent manner (PubMed:20154091, PubMed:22065758). Interacts with DENND1C; weak interaction which is nucleotide-independent (PubMed:20154091). Interacts (GTP-bound form) with ACAP2 and MICALL1; the interaction is direct and probably recruits ACAP2 and MICALL1 to membranes (PubMed:21951725). Interacts with EHD1; the interaction is indirect through MICALL1 and probably recruits EHD1 to membranes.

功能:

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in the process of endocytosis and is an essential rate-limiting regulator of the fast recycling pathway back to the plasma membrane. During cytokinesis, required for the postfurrowing terminal steps, namely for intercellular bridge stability and abscission, possibly by controlling phosphatidylinositol 4,5-bis phosphate (PIP2) and SEPT2 localization at the intercellular bridge. May indirectly regulate neurite outgrowth.

亚细胞位置:

Cell membrane Lipid-anchor Cytoplasmic side Membrane Clathrin-coated pit Cytoplasmic vesicle Clathrin-coated vesicle Endosome Melanosome Present on sorting endosomes and recycling endosome tubules (PubMed:16950109). Tends to be enriched in PIP2-positive cell membrane domains (PubMed:16950109). During mitosis, associated with the plasma membrane and present at the ingressing furrow during early cytokinesis as well as at the intercellular bridge later during cytokinesis (PubMed:16950109). Identified in stage I to stage IV melanosomes (PubMed:17081065).

数据库链接

UniGene:

Hs.524788

SMR:

Q15286

STRING:

9606.ENSP00000229340

KEGG:

hsa:11021

MIM:

604199

Pfam:

PF00071

Uniprot:

Q15286