Human RAB1A/ Ras-related protein Rab-1A CLIA Kit

货号:

商标:

EIAab^®

监管等级:

RUO

别名:

YPT1-related protein, RAB1

检测方法:

CLIA

特异性:

Natural and recombinant human Ras-related protein Rab-1A

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

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Human RAB1A CLIA Kit

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通用注释

亚单元:

May interact with YIPF5. Interacts with C9orf72 (By similarity). Interacts with GDI1; this promotes dissociation from membranes. Interacts with L.pneumophila AnkX, LidA and Lem3. Interacts with L.pneumophila and L.drancourtii LepB; this enhances RAB1A GTPase activity. Interacts with L.pneumophila DrrA; this disrupts the interaction between RAB1A and GDI1 and promotes the exchange of RAB1A-bound GDP with GTP. Interacts with E.coli EspG and S.flexneri VirA; this impairs ER to Golgi trafficking and protein secretion. Identified in a complex composed of RAB1A, ARF6 and E.coli EspG.

功能:

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB1A regulates vesicular protein transport from the endoplasmic reticulum (ER) to the Golgi compartment and on to the cell surface, and plays a role in IL-8 and growth hormone secretion. Regulates the level of CASR present at the cell membrane. Plays a role in cell adhesion and cell migration, via its role in protein trafficking. Plays a role in autophagosome assembly and cellular defense reactions against pathogenic bacteria. Plays a role in microtubule-dependent protein transport by early endosomes and in anterograde melanosome transport.

亚细胞位置:

Golgi apparatus Endoplasmic reticulum Early endosome Cytoplasm Cytosol Membrane Melanosome Alternates between membrane-associated and cytosolic forms.

数据库链接

UniGene:

Hs.310645

SMR:

P62820

STRING:

9606.ENSP00000387286

KEGG:

hsa:5861

MIM:

179508

Pfam:

PF00071

Uniprot:

P62820