RAB1A (基因名), Ras-related protein Rab-1A (蛋白名), rab1a_canlf.
通用注释
亚单元:
Interacts with GDI1; this promotes dissociation from membranes. Interacts with C9orf72 (By similarity). May interact with YIPF5.
功能:
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB1A regulates vesicular protein transport from the endoplasmic reticulum (ER) to the Golgi compartment and on to the cell surface, and plays a role in IL-8 and growth hormone secretion. Regulates the level of CASR present at the cell membrane. Plays a role in cell adhesion and cell migration, via its role in protein trafficking. Plays a role in autophagosome assembly and cellular defense reactions against pathogenic bacteria. Plays a role in microtubule-dependent protein transport by early endosomes and in anterograde melanosome transport.
亚细胞位置:
Golgi apparatus
Endoplasmic reticulum
Early endosome
Cytoplasm
Cytosol
Membrane
Melanosome
Alternates between membrane-associated and cytosolic forms.
数据库链接
UniGene:
SMR:
STRING:
KEGG:
Pfam:
Uniprot:
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