PRPF8 (基因名), Pre-mRNA-processing-splicing factor 8 (蛋白名), prp8_human.
产品名称:
Human PRPF8/ Pre-mRNA-processing-splicing factor 8 CLIA Kit
货号:
-
商标:
EIAab®
监管等级:
别名:
220 kDa U5 snRNP-specific protein, PRP8 homolog, Splicing factor Prp8, p220, PRPC8
检测方法:
CLIA
特异性:
Natural and recombinant human Pre-mRNA-processing-splicing factor 8
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
Epigenetics
通用注释
亚单元:
Part of the U5 snRNP complex. Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39. Component of the U5.U4atac/U6atac snRNP complexes in U12-dependent spliceosomes. Found in a mRNA splicing-dependent exon junction complex (EJC) with SRRM1. Interacts with U5 snRNP proteins SNRP116 and SNRNP40. Interacts with EFTUD2 and SNRNP200. Interacts (via the MPN (JAB/Mov34) domain) with PRPF3 ('Lys-63'-linked polyubiquitinated); may stabilize the U4/U6-U5 tri-snRNP complex.
功能:
Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex. Functions as scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5' and the 3' splice site.
亚细胞位置:
Nucleus speckle
数据库链接
验证序列:
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