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Pik3r2 (基因名), Phosphatidylinositol 3-kinase regulatory subunit beta (蛋白名), p85b_rat.

产品名称:

Rat Pik3r2/ Phosphatidylinositol 3-kinase regulatory subunit beta CLIA Kit

货号:

商标:

EIAab^®

监管等级:

RUO

别名:

Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta, PI3-kinase subunit p85-beta, PI3-kinase regulatory subunit beta

检测方法:

CLIA

特异性:

Natural and recombinant rat Phosphatidylinositol 3-kinase regulatory subunit beta

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

Stem Cells

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Rat Pik3r2 CLIA Kit

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通用注释

亚单元:

Heterodimer of a regulatory subunit PIK3R2 and a p110 catalytic subunit (PIK3CA, PIK3CB or PIK3CD). Interacts with AXL. Interacts with FLT1 (tyrosine-phosphorylated) and FLT4 (tyrosine-phosphorylated). Interacts with NYAP1, NYAP2 and MYO16. Interacts with FBXL2; PIK3R2 is a substrate of the SCF(FBXL2) complex. Interacts with PTPN13; dephosphorylates PIK3R2. Interacts with XBP1; the interaction is direct and induces translocation of XBP1 into the nucleus in a ER stress- and/or insulin-dependent but PI3K-independent manner. Interacts with PIK3R1; the interaction is dissociated in an insulin-dependent manner.

功能:

Regulatory subunit of phosphoinositide-3-kinase (PI3K), a kinase that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Indirectly regulates autophagy. Promotes nuclear translocation of XBP1 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement.

亚细胞位置:

N/A

数据库链接

UniGene:

Rn.22497

SMR:

Q63788

STRING:

10116.ENSRNOP00000026210

Pfam:

PF16454

Uniprot: