Oprl1 (基因名), Nociceptin receptor (蛋白名), oprx_rat.
产品名称:
Rat Oprl1/ Nociceptin receptor CLIA Kit
孤啡肽受体
货号:
U9791r
商标:
EIAab®
监管等级:
别名:
Kappa-type 3 opioid receptor, Orphanin FQ receptor, ROR-C, XOR1, KOR-3, Oor, Oprl
检测方法:
CLIA
特异性:
Natural and recombinant rat Nociceptin receptor
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
-
通用注释
亚单元:
N/A
功能:
G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin.
亚细胞位置:
Cell membrane
Multi-pass membrane protein
Cytoplasmic vesicle
Ligand binding leads to receptor internalization into cytoplasmic vesicles, decreasing the amount of available receptor at the cell surface (By similarity). Internalization requires phosphorylation at Ser-360. Can recycle to the cell membrane.
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