OPRL1 (基因名), Nociceptin receptor (蛋白名), oprx_pig.
产品名称:
Pig OPRL1/ Nociceptin receptor CLIA Kit
孤啡肽受体
货号:
U9791p
商标:
EIAab®
监管等级:
别名:
K3 opiate receptor, Kappa-type 3 opioid receptor, ORGC, Orphanin FQ receptor, KOR-3
检测方法:
CLIA
特异性:
Natural and recombinant pig Nociceptin receptor
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
-
通用注释
亚单元:
N/A
功能:
G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin.
亚细胞位置:
Cell membrane
Multi-pass membrane protein
Cytoplasmic vesicle
Ligand binding leads to receptor internalization into cytoplasmic vesicles, decreasing the amount of available receptor at the cell surface. Internalization requires phosphorylation at Ser-363. Can recycle to the cell membrane (By similarity).
该产品尚未在任何出版物中被引用。
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