Olr1 (基因名), Oxidized low-density lipoprotein receptor 1 (蛋白名), olr1_mouse.
产品名称:
Mouse Olr1/ Oxidized low-density lipoprotein receptor 1 CLIA Kit
氧化低密度脂蛋白受体1
货号:
U1859m
商标:
EIAab®
监管等级:
别名:
Lectin-like oxidized LDL receptor 1, Lectin-type oxidized LDL receptor 1, LOX-1, Ox-LDL receptor 1, Lox1
检测方法:
CLIA
特异性:
Natural and recombinant mouse Oxidized low-density lipoprotein receptor 1
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
Cardiovascular
通用注释
亚单元:
Homodimer; disulfide-linked. May form a hexamer composed of 3 homodimers. Interacts with HSP70.
功能:
Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria.
亚细胞位置:
Cell membrane
Lipid-anchor
Cell membrane
Single-pass type II membrane protein
Membrane raft
Secreted
A secreted form also exists. Localization to membrane rafts requires palmitoylation (By similarity).
数据库链接
UniGene:
SMR:
STRING:
KEGG:
Pfam:
Uniprot:
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