OAS1 (基因名), 2'-5'-oligoadenylate synthase 1 (蛋白名), oas1_pig.
产品名称:
Pig OAS1/ 2'-5'-oligoadenylate synthase 1 CLIA Kit
2 5 -oligoadenylate合成酶1
货号:
U0330p
商标:
EIAab®
监管等级:
别名:
p42 OAS, (2-5')oligo(A) synthase 1
检测方法:
CLIA
特异性:
Natural and recombinant pig 2'-5'-oligoadenylate synthase 1
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
-
通用注释
亚单元:
Monomer. Homotetramer.
功能:
Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. The secreted form displays antiviral effect against vesicular stomatitis virus (VSV), herpes simplex virus type 2 (HSV-2), and encephalomyocarditis virus (EMCV) and stimulates the alternative antiviral pathway independent of RNase L.
亚细胞位置:
Cytoplasm
Mitochondrion
Nucleus
Microsome
Endoplasmic reticulum
Secreted
Associated with different subcellular fractions such as mitochondrial, nuclear, and rough/smooth microsomal fractions.
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