Rat Grin1/ Glutamate receptor ionotropic, NMDA 1 CLIA Kit
谷氨酸[NMDA]受体亚基Ζ1

货号:

U0336r

商标:

EIAab^®

监管等级:

RUO

别名:

Glutamate [NMDA] receptor subunit zeta-1, N-methyl-D-aspartate receptor subunit NR1, NMD-R1, GluN1, Nmdar1

检测方法:

CLIA

实验类型:

Sandwich

检测范围:

39-2500pg/mL

特异性:

Natural and recombinant rat Glutamate receptor ionotropic, NMDA 1

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

Neurosciences

规格 & 价格:

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Rat Grin1 CLIA Kit

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产品说明书

说明书:

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通用注释

亚单元:

Heterotetramer. Forms heterotetrameric channels composed of two zeta subunits (GRIN1), and two epsilon subunits (GRIN2A, GRIN2B, GRIN2C or GRIN2D) (in vitro) (PubMed:18177891, PubMed:28384476, PubMed:16281028, PubMed:15996549, PubMed:21389213, PubMed:24876489, PubMed:27135925, PubMed:28468946, Ref.32). Can also form heterotetrameric channels that contain at least one zeta subunit (GRIN1), an epsilon subunit, plus GRIN3A or GRIN3B (in vitro) (PubMed:11160393, PubMed:11929923, PubMed:12391275). In vivo, the subunit composition may vary in function of the expression levels of the different subunits (Probable). Found in a complex with GRIN2A or GRIN2B, GRIN3A and PPP2CB (PubMed:11588171). Found in a complex with GRIN2A or GRIN2B and GRIN3B (By similarity). Interacts with SNX27 (via PDZ domain); the interaction is required for recycling to the plasma membrane when endocytosed and prevent degradation in lysosomes (By similarity). Interacts with DLG4 and MPDZ (PubMed:15312654). Interacts with LRFN1 and LRFN2 (PubMed:16495444, PubMed:16630835). Interacts with MYZAP (PubMed:18849881). Found in a complex with DLG4 and PRR7 (PubMed:27458189). Found in a complex with GRIN2B and PRR7 (PubMed:27458189). Interacts with PRR7; the interaction is reduced following NMDA receptor activity (PubMed:27458189).

功能:

Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:1350383, PubMed:1834949, PubMed:1388270, PubMed:8428958, PubMed:18177891, PubMed:28384476, PubMed:15996549, PubMed:24876489, PubMed:27135925, PubMed:27618671, PubMed:28468946). Sensitivity to glutamate and channel kinetics depend on the subunit composition (PubMed:28384476).

亚细胞位置:

Cell membrane Multi-pass membrane protein Cell junction Synapse Postsynaptic cell membrane Cell junction Synapse Postsynaptic cell membrane Postsynaptic density Enriched in postsynaptic plasma membrane and postsynaptic densities.

数据库链接

UniGene:

Rn.9840

SMR:

P35439

STRING:

10116.ENSRNOP00000029227

KEGG:

rno:24408

Pfam:

PF01094

Uniprot: