Human NECTIN3/ Nectin-3 CLIA Kit

货号:

商标:

EIAab^®

监管等级:

RUO

别名:

CDw113, Nectin cell adhesion molecule 3, Poliovirus receptor-related protein 3, CD113, PRR3, PVRL3

检测方法:

CLIA

特异性:

Natural and recombinant human Nectin-3

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

关注

Human NECTIN3 CLIA Kit

邮箱 *

消息 *

Please 登录.

产品说明书

在线询价

数据
文献
序列 / 3D
反馈墙 (0)

通用注释

亚单元:

Cis- and trans-homodimer. Can form trans-heterodimers with NECTIN1, NECTIN2, PVR, IGSF4B/Necl-1 and with IGSF4. Interaction between NECTIN1 and NECTIN3 on the pre- and postsynaptic sites, respectively, initiates the formation of puncta adherentia junctions between axons and dendrites. Interacts (via Cytoplasmic domain) with AFDN, providing a connection with the actin cytoskeleton. Binds with low affinity to TIGIT.

功能:

Plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with NECTIN2 at Sertoli-spermatid junctions. Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1. Also involved in the formation of cell-cell junctions, including adherens junctions and synapses. Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. Plays a role in the morphology of the ciliary body.

亚细胞位置:

Cell membrane Single-pass membrane protein Cell junction Synapse Postsynaptic cell membrane

数据库链接

UniGene:

Hs.293917

SMR:

Q9NQS3

STRING:

9606.ENSP00000418070

KEGG:

hsa:25945

MIM: