Map1lc3a (基因名), Microtubule-associated proteins 1A/1B light chain 3A (蛋白名), mlp3a_rat.
产品名称:
Rat Map1lc3a/ Microtubule-associated proteins 1A/1B light chain 3A CLIA Kit
HumanMicrotubule-associatedproteins1A/1Blightchain3A
货号:
U2879r
商标:
EIAab®
监管等级:
别名:
Autophagy-related protein LC3 A, Autophagy-related ubiquitin-like modifier LC3 A, MAP1 light chain 3-like protein 1, MAP1A/MAP1B light chain 3 A, Microtubule-associated protein 1 light chain 3 alpha, MAP1A/MAP1B LC3 A
检测方法:
CLIA
特异性:
Natural and recombinant rat Microtubule-associated proteins 1A/1B light chain 3A
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
Cancer
通用注释
亚单元:
3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins (By similarity). Interacts with TP53INP2 (By similarity). Interacts with TP53INP1 and SQSTM1 (PubMed:22421968). Directly interacts with SQSTM1; this interaction leads to MAP1LC3A recruitment to inclusion bodies containing polyubiquitinated protein aggregates and to inclusion body degradation by autophagy (By similarity). Interacts with ATG13 and ULK1 (By similarity). Interacts with TBC1D5 (By similarity). Found in a complex with UBQLN1 and UBQLN2 (By similarity). Interacts with UBQLN4 (via STI1 1 and 2 domains) (By similarity). Interacts with UBQLN1 in the presence of UBQLN4 (By similarity). Interacts with TRIM5 (By similarity). Interacts with MEFV. Interacts with FAM134A, FAM134B and FAM134C.
功能:
Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation.
亚细胞位置:
Cytoplasm
Cytoskeleton
Endomembrane system
Lipid-anchor
Cytoplasmic vesicle
Autophagosome membrane
Lipid-anchor
Cytoplasmic vesicle
Autophagosome
LC3-II binds to the autophagic membranes.
数据库链接
UniGene:
SMR:
STRING:
KEGG:
Pfam:
Uniprot:
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