MITF (基因名), Microphthalmia-associated transcription factor (蛋白名), mitf_human.
产品名称:
Human MITF/ Microphthalmia-associated transcription factor CLIA Kit
Microphthalmia-associated转录因子
货号:
U0547h
商标:
EIAab®
监管等级:
别名:
Class E basic helix-loop-helix protein 32, bHLHe32, BHLHE32
检测方法:
CLIA
实验类型:
Sandwich
检测范围:
78-5000pg/mL
特异性:
Natural and recombinant human Microphthalmia-associated transcription factor
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
Immunology
通用注释
亚单元:
Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA in the form of homodimer or heterodimer with either TFE3, TFEB or TFEC. Interacts with KARS. Identified in a complex with HINT1 and CTNNB1.
功能:
Transcription factor that regulates the expression of genes with essential roles in cell differentiation, proliferation and survival. Binds to M-boxes (5'-TCATGTG-3') and symmetrical DNA sequences (E-boxes) (5'-CACGTG-3') found in the promoters of target genes, such as BCL2 and tyrosinase (TYR). Plays an important role in melanocyte development by regulating the expression of tyrosinase (TYR) and tyrosinase-related protein 1 (TYRP1). Plays a critical role in the differentiation of various cell types, such as neural crest-derived melanocytes, mast cells, osteoclasts and optic cup-derived retinal pigment epithelium.
亚细胞位置:
Nucleus
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