Human LGALS8/ Galectin-8 CLIA Kit
Galectin-8

货号:

U1108h

商标:

EIAab^®

监管等级:

RUO

别名:

Po66 carbohydrate-binding protein, Prostate carcinoma tumor antigen 1, Po66-CBP, PCTA-1, Gal-8

检测方法:

CLIA

实验类型:

Sandwich

检测范围:

62.5-4000pg/mL

特异性:

Natural and recombinant human Galectin-8

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

规格 & 价格:

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Human LGALS8 CLIA Kit

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产品说明书

说明书:

MSDS:

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通用注释

亚单元:

Homodimer (PubMed:21288902, Ref.14). Interacts with CALCOCO2/NDP52 (PubMed:22246324).

功能:

Beta-galactoside-binding lectin that acts as a sensor of membrane damage caused by infection and restricts the proliferation of infecting pathogens by targeting them for autophagy (PubMed:22246324, PubMed:28077878). Detects membrane rupture by binding beta-galactoside ligands located on the lumenal side of the endosome membrane; these ligands becoming exposed to the cytoplasm following rupture (PubMed:22246324, PubMed:28077878). Restricts infection by initiating autophagy via interaction with CALCOCO2/NDP52 (PubMed:22246324, PubMed:28077878). Required to restrict infection of bacterial invasion such as S.typhimurium (PubMed:22246324). Also required to restrict infection of Picornaviridae viruses (PubMed:28077878). Has a marked preference for 3'-O-sialylated and 3'-O-sulfated glycans (PubMed:21288902).

亚细胞位置:

Cytoplasmic vesicle Cytoplasm Cytosol

数据库链接

UniGene:

Hs.4082

SMR:

O00214

KEGG:

hsa:3964

MIM:

606099

Pfam: