Ldlr (基因名), Low-density lipoprotein receptor (蛋白名), ldlr_mouse.
产品名称:
Mouse Ldlr/ Low-density lipoprotein receptor CLIA Kit
低密度脂蛋白受体
货号:
U1008m
商标:
EIAab®
监管等级:
别名:
LDL receptor
检测方法:
CLIA
特异性:
Natural and recombinant mouse Low-density lipoprotein receptor
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
-
通用注释
亚单元:
Interacts (via NPXY motif) with DAB2 (via PID domain); the interaction is impaired by tyrosine phosphorylation of the NPXY motif (PubMed:11247302). Interacts (via NPXY motif) with LDLRAP1 (via PID domain) (By similarity). Interacts with ARRB1 (By similarity). Interacts with SNX17 (PubMed:12169628). Interacts with the full length immature form of PCSK9 (via C-terminus).
功能:
Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits.
亚细胞位置:
Cell membrane
Single-pass type I membrane protein
Membrane
Clathrin-coated pit
Golgi apparatus
Early endosome
Late endosome
Lysosome
Rapidly endocytosed upon ligand binding.
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