LCAT (基因名), Phosphatidylcholine-sterol acyltransferase (蛋白名), lcat_human.
产品名称:
Human LCAT/ Phosphatidylcholine-sterol acyltransferase CLIA Kit
Phosphatidylcholine-sterol酰基转移酶
货号:
U2114h
商标:
EIAab®
监管等级:
别名:
Lecithin-cholesterol acyltransferase, Phospholipid-cholesterol acyltransferase
检测方法:
CLIA
特异性:
Natural and recombinant human Phosphatidylcholine-sterol acyltransferase
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
Cardiovascular
通用注释
亚单元:
N/A
功能:
Central enzyme in the extracellular metabolism of plasma lipoproteins. Synthesized mainly in the liver and secreted into plasma where it converts cholesterol and phosphatidylcholines (lecithins) to cholesteryl esters and lysophosphatidylcholines on the surface of high and low density lipoproteins (HDLs and LDLs) (PubMed:10329423, PubMed:19065001, PubMed:26195816). The cholesterol ester is then transported back to the liver. Has a preference for plasma 16:0-18:2 or 18:O-18:2 phosphatidylcholines (PubMed:8820107). Also produced in the brain by primary astrocytes, and esterifies free cholesterol on nascent APOE-containing lipoproteins secreted from glia and influences cerebral spinal fluid (CSF) APOE- and APOA1 levels. Together with APOE and the cholesterol transporter ABCA1, plays a key role in the maturation of glial-derived, nascent lipoproteins. Required for remodeling high-density lipoprotein particles into their spherical forms (PubMed:10722751).
亚细胞位置:
Secreted
Secreted into blood plasma (PubMed:3458198, PubMed:8820107, PubMed:10222237). Produced in astrocytes and secreted into cerebral spinal fluid (CSF).
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