Human KSR1/ Kinase suppressor of Ras 1 CLIA Kit
Ras激酶抑制剂1

货号:

U14081h

商标:

EIAab^®

监管等级:

RUO

别名:

KSR

检测方法:

CLIA

实验类型:

Sandwich

检测范围:

78-5000pg/ml

特异性:

Natural and recombinant human Kinase suppressor of Ras 1

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

Cancer

规格 & 价格:

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Human KSR1 CLIA Kit

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产品说明书

说明书:

MSDS:

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通用注释

亚单元:

Interacts with HSP90AA1/HSP90, YWHAE/14-3-3, CDC37, MAP2K1/MEK-1 and MAP2K2/MEK-2 (PubMed:10409742). Interacts with MARK3, PPP2R1A and PPP2CA. Also interacts with RAF and MAPK/ERK, in a Ras-dependent manner. The binding of 14-3-3 proteins to phosphorylated KSR prevents the membrane localization (By similarity). Interacts with isoform 1 of VRK2 (PubMed:20679487). Interacts with AKAP13 and BRAF (PubMed:21102438). Identified in a complex with AKAP13, MAP2K1 and BRAF.

功能:

Scaffolding protein that is part of a multiprotein signaling complex. Promotes phosphorylation of Raf family members and activation of downstream MAP kinases. Promotes activation of MAPK1 and/or MAPK3, both in response to EGF and to cAMP. Does not have kinase activity by itself.

亚细胞位置:

Cytoplasm Membrane Peripheral membrane protein Cell membrane Peripheral membrane protein Cell projection Ruffle membrane Endoplasmic reticulum membrane In unstimulated cells, where the phosphorylated form is bound to a 14-3-3 protein, sequestration in the cytoplasm occurs. Following growth factor treatment, the protein is free for membrane translocation, and it moves from the cytoplasm to the cell periphery.

数据库链接

UniGene:

Hs.133534

SMR:

Q8IVT5

STRING:

9606.ENSP00000323178

KEGG:

hsa:8844

MIM:

601132

Pfam: