Mouse Kirrel3/ Kin of IRRE-like protein 3 CLIA Kit

货号:

U4427m

商标:

EIAab^®

监管等级:

RUO

别名:

Kin of irregular chiasm-like protein 3, Nephrin-like protein 2, mKirre, Kiaa1867, Neph2

检测方法:

CLIA

特异性:

Natural and recombinant mouse Kin of IRRE-like protein 3

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

规格 & 价格:

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Mouse Kirrel3 CLIA Kit

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通用注释

亚单元:

Homodimer; mediates homophilic interactions to promote cell adhesion (PubMed:26575286). Interacts with NPHS1; forms heterodimers with NPHS1 (PubMed:15843475, PubMed:18752272). Interacts with NPHS2/podocin (via the C-terminus) (By similarity). Interacts with CASK. Interacts (via extracellular region) with MAP1B. Interacts (via extracellular region) with MYO16. Interacts (via intracellular region) with ATP1B1. Interacts (via intracellular region) with SHMT2. Interacts (via intracellular region) with UFC1.

功能:

Synaptic adhesion molecule required for the formation of target-specific synapses (PubMed:23637329, PubMed:26575286). Required for formation of target-specific synapses at hippocampal mossy fiber synapses. Required for formation of mossy fiber filopodia, the synaptic structures connecting dentate granule and GABA neurons. Probably acts as a homophilic adhesion molecule that promotes trans-cellular interactions and stabilize mossy fiber filipodia contact and subsequent synapse formation (PubMed:26575286). Required for the coalescence of vomeronasal sensory neuron axons (PubMed:23637329). May be involved in the hematopoietic supportive capacity of stroma cells; the secreted extracellular domain is directly responsible for supporting hematopoietic stem cells (PubMed:12665856).

亚细胞位置:

Processed kin of IRRE-like protein 3 Secreted

数据库链接

UniGene:

Mm.220710

STRING:

10090.ENSMUSP00000110801

KEGG:

mmu:67703

Pfam:

PF07679

Uniprot: