Human KIN/ DNA/RNA-binding protein KIN17 CLIA Kit

货号:

U15920h

商标:

EIAab^®

监管等级:

RUO

别名:

Binding to curved DNA, KIN, antigenic determinant of recA protein homolog, BTCD, KIN17

检测方法:

CLIA

特异性:

Natural and recombinant human DNA/RNA-binding protein KIN17

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

规格 & 价格:

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Human KIN CLIA Kit

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通用注释

亚单元:

Interacts with SV40 large T antigen. Associated with DNA polymerase alpha, RFC1 and cyclin A, in multiprotein DNA replication complexes. Also associates with replication origins at the G1/S phase boundary and throughout the S phase in vivo.

功能:

Involved in DNA replication and the cellular response to DNA damage. May participate in DNA replication factories and create a bridge between DNA replication and repair mediated by high molecular weight complexes. May play a role in illegitimate recombination and regulation of gene expression. May participate in mRNA processing. Binds, in vitro, to double-stranded DNA. Also shown to bind preferentially to curved DNA in vitro and in vivo (By similarity). Binds via its C-terminal domain to RNA in vitro.

亚细胞位置:

Nucleus Cytoplasm During S phase, strongly associated with the nuclear matrix, and to chromosomal DNA in the presence of DNA damage. Also shows cytoplasmic localization in elongated spermatids.

数据库链接

UniGene:

Hs.397918

SMR:

O60870

STRING:

9606.ENSP00000368881

KEGG:

hsa:22944

MIM:

601720

Pfam: