Human KIF5A/ Kinesin heavy chain isoform 5A CLIA Kit
驱动蛋白重链异构体5A

货号:

U0155h

商标:

EIAab^®

监管等级:

RUO

别名:

Kinesin heavy chain neuron-specific 1, Neuronal kinesin heavy chain, NKHC, NKHC1

检测方法:

CLIA

实验类型:

Sandwich

检测范围:

39-2500pg/mL

特异性:

Natural and recombinant human Kinesin heavy chain isoform 5A

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

规格 & 价格:

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Human KIF5A CLIA Kit

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产品说明书

说明书:

MSDS:

在线询价

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通用注释

亚单元:

Oligomer composed of two heavy chains and two light chains. Interacts with GRIP1. Interacts with FMR1 (via C-terminus); this interaction is increased in a mGluR-dependent manner. Interacts with ZFYVE27. Interacts with VAPA, VAPB, SURF4, RAB11A (GDP-bound form), RAB11B (GDP-bound form) and RTN3 in a ZFYVE27-dependent manner (By similarity). Interacts with BORCS5 (PubMed:25898167). Interacts with BICD2 (PubMed:20386726).

功能:

Microtubule-dependent motor required for slow axonal transport of neurofilament proteins (NFH, NFM and NFL). Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner. The ZFYVE27-KIF5A complex contributes to the vesicular transport of VAPA, VAPB, SURF4, RAB11A, RAB11B and RTN3 proteins in neurons.

亚细胞位置:

Cytoplasm Perinuclear region Cytoplasm Cytoskeleton Concentrated in the cell body of the neurons, particularly in the perinuclear region.

数据库链接

UniGene:

Hs.151219

SMR:

Q12840

STRING:

9606.ENSP00000408979

KEGG:

hsa:3798

MIM: