KEAP1 (基因名), Kelch-like ECH-associated protein 1 (蛋白名), keap1_pig.
产品名称:
Pig KEAP1/ Kelch-like ECH-associated protein 1 CLIA Kit
Kelh样ECH相关蛋白1
货号:
U2835p
商标:
EIAab®
监管等级:
别名:
Cytosolic inhibitor of Nrf2, INrf2, INRF2
检测方法:
CLIA
特异性:
Natural and recombinant pig Kelch-like ECH-associated protein 1
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
-
通用注释
亚单元:
Homodimer. Forms a ternary complex with NFE2L2 and PGAM5. Interacts with the N-terminal regulatory domain of NFE2L2/NRF2. Interacts with BPTF and PTMA. Interacts with CUL3. Part of a complex that contains KEAP1, CUL3 and RBX1. Interacts indirectly with ENC1. Interacts with MAP1LC3B. Interacts with SESN1 and SESN2. Interacts with HSP90AA1 and HSP90AB1.
功能:
Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome.
亚细胞位置:
Cytoplasm
Nucleus
Shuttles between cytoplasm and nucleus.
数据库链接
UniGene:
SMR:
STRING:
KEGG:
Pfam:
Uniprot:
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