KDM5B (基因名), Lysine-specific demethylase 5B (蛋白名), kdm5b_human.
产品名称:
Human KDM5B/ Lysine-specific demethylase 5B CLIA Kit
货号:
U12891h
商标:
EIAab®
监管等级:
别名:
Cancer/testis antigen 31, Histone demethylase JARID1B, Jumonji/ARID domain-containing protein 1B, PLU-1, Retinoblastoma-binding protein 2 homolog 1, CT31, RBP2-H1, JARID1B, PLU1, RBBP2H1
检测方法:
CLIA
特异性:
Natural and recombinant human Lysine-specific demethylase 5B
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
-
通用注释
亚单元:
Interacts with FOXG1B, PAX9, MYC, MYCN and RB1. Interacts with HDAC1, HDAC4, HDAC5 and HDAC7.
功能:
Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2.
亚细胞位置:
Nucleus
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