Kdm3a (基因名), Lysine-specific demethylase 3A (蛋白名), kdm3a_rat.
产品名称:
Rat Kdm3a/ Lysine-specific demethylase 3A CLIA Kit
货号:
-
商标:
EIAab®
监管等级:
别名:
JmjC domain-containing histone demethylation protein 2A, Jumonji domain-containing protein 1A, Testis-specific gene A protein, Zinc finger protein TSGA, Jhdm2a, Jmjd1a, Tsga
检测方法:
CLIA
特异性:
Natural and recombinant rat Lysine-specific demethylase 3A
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
-
通用注释
亚单元:
N/A
功能:
Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Preferentially demethylates mono- and dimethylated H3 'Lys-9' residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 'Lys-9'. Demethylation of Lys residue generates formaldehyde and succinate. Involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 'Lys-9' demethylation and transcriptional activation. Involved in spermatogenesis by regulating expression of target genes such as PRM1 and TMP1 which are required for packaging and condensation of sperm chromatin. Directly regulates expression of PPARA and UCP1 and is involved in obesity resistance.
亚细胞位置:
Cytoplasm
Nucleus
Nuclear in round spermatids. When spermatids start to elongate, localizes to the cytoplasm where it forms distinct foci which disappear in mature spermatozoa (By similarity).
数据库链接
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