Mouse Kcnk2/ Potassium channel subfamily K member 2 CLIA Kit

货号:

U14317m

商标:

EIAab^®

监管等级:

RUO

别名:

Outward rectifying potassium channel protein TREK-1, TREK-1 K(+) channel subunit, Two pore potassium channel TPKC1

检测方法:

CLIA

特异性:

Natural and recombinant mouse Potassium channel subfamily K member 2

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

规格 & 价格:

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Mouse Kcnk2 CLIA Kit

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通用注释

亚单元:

Homodimer; disulfide-linked (PubMed:24496152). Heterodimer with KCNK1; disulfide-linked (PubMed:24496152). Interacts with BVES; the interaction enhances KCNK2 surface expression and is inhibited by cAMP (PubMed:22354168, PubMed:26642364).

功能:

Ion channel that contributes to passive transmembrane potassium transport. Reversibly converts between a voltage-insensitive potassium leak channel and a voltage-dependent outward rectifying potassium channel in a phosphorylation-dependent manner. In astrocytes, forms mostly heterodimeric potassium channels with KCNK1, with only a minor proportion of functional channels containing homodimeric KCNK2 (PubMed:24496152). In astrocytes, the heterodimer formed by KCNK1 and KCNK2 is required for rapid glutamate release in response to activation of G-protein coupled receptors, such as F2R and CNR1 (PubMed:24496152).

亚细胞位置:

Isoform 2 Cell membrane Multi-pass membrane protein

数据库链接

UniGene:

Mm.33304

SMR:

P97438

STRING:

10090.ENSMUSP00000078416

KEGG:

mmu:16526

Pfam: