Kcnj4 (基因名), Inward rectifier potassium channel 4 (蛋白名), kcnj4_mouse.
产品名称:
Mouse Kcnj4/ Inward rectifier potassium channel 4 CLIA Kit
货号:
-
商标:
EIAab®
监管等级:
别名:
Inward rectifier K(+) channel Kir2.3, Potassium channel, inwardly rectifying subfamily J member 4, IRK-3, Irk3
检测方法:
CLIA
特异性:
Natural and recombinant mouse Inward rectifier potassium channel 4
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
-
通用注释
亚单元:
Homomultimeric and heteromultimeric association with KCNJ2 and KCNJ12. Association, via its PDZ-recognition domain, with LIN7A, LIN7B, LIN7C, DLG1, DLG2, DLG4, CASK and APBA1 plays a key role in its localization and trafficking (By similarity). Interacts with TAX1BP3. TAX1BP3 competes with LIN7 family members for KCNJ4 binding.
功能:
Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium.
亚细胞位置:
Cell membrane
Multi-pass membrane protein
Cell junction
Synapse
Postsynaptic cell membrane
Multi-pass membrane protein
Cytoplasmic vesicle membrane
TAX1BP3 binding promotes dissociation of KCNJ4 from LIN7 family members and KCNJ4 internalization.
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