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KCNE1 (基因名), Potassium voltage-gated channel subfamily E member 1 (蛋白名), kcne1_pig.

产品名称:

Pig KCNE1/ Potassium voltage-gated channel subfamily E member 1 CLIA Kit

货号:

商标:

EIAab^®

监管等级:

RUO

别名:

Delayed rectifier potassium channel subunit IsK, IKs producing slow voltage-gated potassium channel subunit beta Mink, Minimal potassium channel

检测方法:

CLIA

特异性:

Natural and recombinant pig Potassium voltage-gated channel subfamily E member 1

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

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通用注释

亚单元:

Interacts with KCNB1. Interacts with KCNC2 (By similarity). Associates with KCNH2/HERG. Interacts with KCNQ1; targets the complex KNCQ1-KCNE1 to the membrane raft.

功能:

Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. Assembled with KCNQ1/KVLQT1 is proposed to form the slowly activating delayed rectifier cardiac potassium (IKs) channel. The outward current reaches its steady state only after 50 seconds. Assembled with KCNH2/HERG may modulate the rapidly activating component of the delayed rectifying potassium current in heart (IKr).

亚细胞位置:

Cell membrane Single-pass type I membrane protein Apical cell membrane Membrane raft Colocalizes with KCNB1 at the plasma membrane (By similarity). Targets to the membrane raft when associated with KNCQ1 (By similarity).

数据库链接

UniGene:

Ssc.15995

SMR:

Q9TUH9

KEGG:

ssc:397331

Pfam:

PF02060

Uniprot:

Q9TUH9