Kcnb2 (基因名), Potassium voltage-gated channel subfamily B member 2 (蛋白名), kcnb2_rat.
产品名称:
Rat Kcnb2/ Potassium voltage-gated channel subfamily B member 2 CLIA Kit
钾电压阀门通道亚家族B成员2
货号:
U2325r
商标:
EIAab®
监管等级:
别名:
CDRK, Voltage-gated potassium channel subunit Kv2.2
检测方法:
CLIA
特异性:
Natural and recombinant rat Potassium voltage-gated channel subfamily B member 2
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
-
通用注释
亚单元:
Homotetramer or heterotetramer with KCNB1 (PubMed:20202934). Heterotetramer with KCNS1 and KCNS2 (PubMed:9305895).
功能:
Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and smooth muscle cells (PubMed:1550672). Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient. Homotetrameric channels mediate a delayed-rectifier voltage-dependent outward potassium current that display rapid activation and slow inactivation in response to membrane depolarization (PubMed:1550672). Can form functional homotetrameric and heterotetrameric channels that contain variable proportions of KCNB1; channel properties depend on the type of alpha subunits that are part of the channel (PubMed:20202934). Can also form functional heterotetrameric channels with other alpha subunits that are non-conducting when expressed alone, such as KCNS1 and KCNS2, creating a functionally diverse range of channel complexes (PubMed:9305895). In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Contributes to the delayed-rectifier voltage-gated potassium current in cortical pyramidal neurons and smooth muscle cells (PubMed:1550672, PubMed:20202934).
亚细胞位置:
Cell membrane
Multi-pass membrane protein
Perikaryon
Cell projection
Dendrite
Localized uniformly throughout cell bodies and dendrites (PubMed:10719893). Colocalizes with KCNB1 to high-density somatodendritic clusters on cortical pyramidal neurons (PubMed:20202934).
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