KCNB2 (基因名), Potassium voltage-gated channel subfamily B member 2 (蛋白名), kcnb2_bovin.
产品名称:
Bovine KCNB2/ Potassium voltage-gated channel subfamily B member 2 CLIA Kit
钾电压阀门通道亚家族B成员2
货号:
U2325b
商标:
EIAab®
监管等级:
检测方法:
CLIA
特异性:
Natural and recombinant bovine Potassium voltage-gated channel subfamily B member 2
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
-
通用注释
亚单元:
Homotetramer or heterotetramer with KCNB1. Heterotetramer with KCNS1 and KCNS2.
功能:
Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and smooth muscle cells. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient. Homotetrameric channels mediate a delayed-rectifier voltage-dependent outward potassium current that display rapid activation and slow inactivation in response to membrane depolarization. Can form functional homotetrameric and heterotetrameric channels that contain variable proportions of KCNB1; channel properties depend on the type of alpha subunits that are part of the channel. Can also form functional heterotetrameric channels with other alpha subunits that are non-conducting when expressed alone, such as KCNS1 and KCNS2, creating a functionally diverse range of channel complexes. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Contributes to the delayed-rectifier voltage-gated potassium current in cortical pyramidal neurons and smooth muscle cells.
亚细胞位置:
Cell membrane
Multi-pass membrane protein
Perikaryon
Cell projection
Dendrite
Localized uniformly throughout cell bodies and dendrites. Colocalizes with KCNB1 to high-density somatodendritic clusters on cortical pyramidal neurons.
数据库链接
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